报告题目：Structure and Characterization of the Proteins in the Ubiquitin System

报告时间：2015年11月29日（周日）18：30-19：30

报告地点：主楼三楼会议室

报 告 人：韩聪 博士

          （英国Dundee大学）

主 持 人：游松教授

主办单位：生命科学与生物制药学院生物制药系

研究生处（学科建设办公室）

          辽宁省现代药物领域研究生创新与交流中心

聆听无涯论坛  拓宽学术视野

欢迎各位老师和同学们踊跃参加！

报告人简介

Dr. Cong Han

Postdoctoral Research Assistant

Education

2006 Ph.D. Biochemistry Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

2003 M.S. Microbiology Shenyang Pharmaceutical University, Shenyang, China

2000 B.S. Pharmacy Shenyang Pharmaceutical University, Shenyang, China

Course and Workshop

1. Practical Course on High Throughput Recombinant Protein Production for Protein-Protein and Protein-Nucleic Acid Complexes,November 25-29, 2013, AFMB, CNRS and Aix-Marseille Université, Marseille, France

2. Structural Biology at the ESRF: Past, Present & Future, February 3-5, 2014, ESRF, Grenoble, France

3. Integrative structural biology tools for the study of protein-ligand interactions, October 6-12, 2014, Universidade NOVA de Lisboa, Caparica, Portugal

Postdoctoral Training

Nov. 2012-current Protein CrystallographyMRC-PPU, University of Dundee, UK

Oct. 2009-Sept. 2012 Protein Crystallography Institute of Integrative Biology, University of Liverpool, UK

Sept.2006-Sept.2009 Protein Crystallography Institutes of Biomedical Sciences,Fudan University, China

Publications

1)Han C., PaoK., Kazlauskaite A., Muqit M.K., Virdee S.A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterization. ChemBioChem, 2015, 16(11):1574-1579.

2) Stanley M., Han C., Knebel A., Wood N., Virdee S.Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes.ACS Chemical Biology, 2015, 10(6):1542-1554.

3) Antonyuk S.V.*, Han C.*, EadyR.R., Hasnain S. Structures ofprotein-protein complexes involved in electron transfer. Nature, 2013,496(7443):123-126. * Equalcontribution.

4) HanC., WrightG., Fisher K., RigbyS., EadyR., HasnainS.Characterization of a novel copper heme cdissimilatory nitritereductase from Ralstonia pickettii. Biochemical Journal, 2012, 444(2): 219-226.

5) Han C., Hu T., Wu D., Qu S., Zhou J., Ding J., Shen X., Qu D., Jiang H. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis: implications for substrate binding and conformational change. FEBS Journal, 2009, 276(4): 1125-1139.

6)Han C., Zhang J., Chen L., Chen K., Shen X., Jiang H. Discovery of Helicobacter pylorishikimate kinase inhibitors: bioassay and molecular modeling. Bioorganic & Medicinal Chemistry, 2007, 15(2): 656-662.

7) Han C., Wang L., Yu K., Chen L., Hu L., Chen K., Jiang H., Shen X. Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS Journal, 2006, 273(20): 4682-4692.

8) Cai J*, Han C*, Hu T, Zhang J, Wu D, Wang F, Liu Y, Ding J, Chen K, Yue J, Shen X, Jiang H. Peptide deformylase is a potential target for anti-Helicobacter pyloridrugs: reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Science, 2006, 15(9):2071-2081.Equalcontribution.

9) Han C., Wang Q., Dong L., Sun H., Peng S., Chen J., Yang Y., Yue J., Shen X., Jiang H. Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori. Biochemical and Biophysical Research Communications, 2004, 319(4): 1292-1298.