报告题目：Tailored Ionic Liquids, A Brief Account (功能性离子液体的开发与应用)

报告时间：2015年7月14日（周二） 15:00-16:00

报告地点：老科研楼五楼研究生学术报告厅（原科六）

报 告 人：朱延和 教授

        （台湾中正大学）

主办单位：基于靶点的药物设计与研究教育部重点实验室

研究生处（学科建设办公室）        

辽宁省研究生现代药物领域创新与交流中心

报告人简介

Yen-Ho Chu (朱延和) is a Professor of Chemistry and Biochemistry at National Chung Cheng University in Taiwan.  He received his B.S. in Chemistry from National Tsing Hua University, M.S. in Biochemical Sciences from National Taiwan University (with Professor Kung-Tsung Wang), and Ph.D. in 1993 from Harvard University (with Professor George M. Whitesides). He was a Postdoctoral Fellow with Professor Christopher T. Walsh at Harvard Medical School, Staff Scientist with Professor Barry L. Karger at the Barnett Institute, and Assistant Professor at Ohio State University from 1995 to 1999.  His research interests include biomolecular recognition, combinatorial organic synthesis, and ionic liquids.

报告内容简介

This presentation highlights our recent progress on ionic liquid research.^[1-3] Ionic liquids are organic salts and many of them are liquid at ambient temperature.^[1] Compared with conventional molecular solvents, ionic liquids carry a number of attractive properties such as remarkable solubility with small molecules, good thermal stability, high polarity and conductivity, and negligible vapor pressure that are suited for a myriad of favorable applications, including reaction media for organic synthesis, affinity interaction analysis of peptides and small proteins, chemoselective gas sensing, electrolytes for rechargeable lithium ion batteries, solvents for cellulose dissolution, and PCR enhancers for DNA amplification.^[1,2]

Ionic liquids offer a platform of tunable structures on which properties and functions of both cation and anion can be independently engineered. We have employed, for example, affinity ionic liquids and sensing ionic liquids to explore functionalized ionic liquids through incorporation of functional groups as a part of developing ionic liquids possessing tailored properties. In this presentation, we are to describe our recent development of chemically stable ionic liquids and their applications for chemoselective gas sensing by quartz crystal microbalance (QCM),^[3] affinity extraction of peptides and proteins, and PCR amplification of DNA.

References

[1]   For our recent reviews on ionic liquids, see: (a) Sowmiah S, Cheng C, Chu Y-H, Curr. Org. Syn., 2012, 9: 74-95; (b) Sowmiah S, Srinivasadesikan V, Tseng M-C, Chu Y-H, Molecules, 2009, 14: 3780-3813.

[2]    (a) Tseng M-C, Chu Y-H, Anal. Chem., 2014, 86: 1949-1952; (b) Liu Y-L, Tseng M-C, Chu Y-H, Chem. Commun., 2013, 49: 2560-2562; (c) Shi Y, Liu Y-L, Lai P-Y, Tseng M-C, Tseng M-J, Li Y, Chu Y-H, Chem. Chemmun., 2012, 48: 5325-5327; (d) Tseng M-C, Cheng H-T, Shen M-J, Chu Y-H, Org. Lett., 2011, 13: 4434-4437; (e) Chen C-W, Tseng M-C, Hsiao S-K, Chen W-H, Chu Y-H, Org. Biomol. Chem., 2011, 9: 4188-4193; (f) Tseng M-C, Chu Y-H, Chem. Commun., 2010, 4: 2983-2985; (g) Tseng M-C, Tseng M-J, Chu Y-H, Chem. Commun., 2009, 7503-7505.

[3]   Cheng C, Chang Y-P, Chu Y-H, Chem. Soc. Rev., 2012, 41: 1947-1971